We aim to improve health care by better understanding the causes of, and solutions to, gaps between research evidence and its application in practice.

To achieve this, we:

  • Undertake research that more closely aligns evidence and patient care.
  • Support and extend collaborations between clinicians and health researchers to achieve better value care.
  • Enable patients and families to make evidence-informed health decisions that are congruent with their values and preferences.
  • Lead and facilitate the teaching and learning of evidence-based practice.
  • Develop young researchers for research programs in sustainable health care.

To deliver these aims, we will generate new research evidence on four big neglected problems in healthcare.

  1. Antibiotic resistance: which currently leads to over 25,000 avoidable deaths per year in both Europe and the USA, threatening elective surgery, and a resurgence of the bacterial diseases of the 19th century.
  2. Overdiagnosis: which has led to massive increase in the apparent prevalence of many diseases through definition change and overdetection, causing much harm and rising health care costs.
  3. Neglected non-pharmaceutical treatments: which are often as effective or more effective than their pharmaceutical cousins, but are poorly described, poorly “marketed”, and little used.
  4. Waste in Medical Research: which we have estimated as over $100Billion per year resulting from avoidable design flaws, non-publication and poor reporting.