We aim to improve healthcare by better understanding the causes of, and solutions to, gaps between research evidence and its application in practice.

To achieve this, we:

  • Undertake research that more closely aligns evidence and patient care.
  • Support and extend collaborations between clinicians and health researchers to achieve higher value care.
  • Enable patients and families to make evidence-informed health decisions that are congruent with their values and preferences.
  • Lead and facilitate the teaching and learning of evidence-based practice.
  • Develop young researchers for research programs in sustainable health care.

To deliver these aims, we will both synthesise and generate new evidence on four neglected problems in healthcare.

  1. Antibiotic resistance: which currently leads to over 30,000 avoidable deaths per year in both Europe and the USA, threatening elective surgery, and a resurgence of the bacterial diseases of the 19th century.
  2. Overdiagnosis: which has led to massive increase in the apparent prevalence of many diseases through definition change and overdetection, causing harm and rising healthcare costs.
  3. Neglected non-pharmaceutical treatments: which are often as effective and as safe, or safer than their pharmaceutical cousins, but are poorly described, poorly “marketed”, and therefore, little used.
  4. Waste in Medical Research: is estimated to cost > $100 billion per year from avoidable design flaws, non-publication and poor reporting, resulting in >85% avoidable waste.